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. 2014 Jun;43(2):185-99.
doi: 10.1016/j.gtc.2014.02.010. Epub 2014 Mar 24.

Eosinophilic esophagitis: historical perspective on an evolving disease

Stephen E Attwood  1 , Glenn T Furuta  2
Affiliations

Eosinophilic esophagitis: historical perspective on an evolving disease

Stephen E Attwood et al. Gastroenterol Clin North Am. 2014 Jun.

Abstract

Initial case series describing children and adults with symptoms related to esophageal dysfunction and dense esophageal eosinophilia lead to recognition of a "new" disease, eosinophilic esophagitis (EoE). Clinical, basic, and translational studies have provided a deeper understanding of this somewhat enigmatic disease that mechanistically is defined as an antigen-driven condition limited to the esophagus. This article summarizes many of the key historical features of EoE and provides a glimpse of potential future developments.

Keywords: Dysphagia; Eosinophilic esophagitis; Eosinophilic oesophagitis; Food bolus obstruction.

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References

    1. Biller JA, Winter HS, Grand RJ, et al. Are endoscopic changes predictive of histologic esophagitis in children? J Pediatr. 1983;103:215–218. - PubMed
    1. Brown LF, Goldman H, Antonioli DA. Intraepithelial eosinophils in endoscopic biopsies of adults with reflux esophagitis. Am J Surg Pathol. 1984;8:899–905. - PubMed
    1. Lee RG. Marked eosinophilia in esophageal mucosal biopsies. Am J Surg Pathol. 1985;9:475–9. - PubMed
    1. Landres RT, Kuster GG, Strum WB. Eosinophilic esophagitis in a patient with vigorous achalasia. Gastroenterology. 1978;74:1298–1301. - PubMed
    1. Picus D, Frank PH. Eosinophilic esophagitis. AJR Am J Roentgenol. 1981;136:1001–3. - PubMed

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