Clinical presentation of eosinophilic esophagitis in adults

Abstract

Eosinophilic esophagitis (EoE) is an increasingly recognized immune antigen-mediated esophageal disease found in both children and adults. It is defined as a clinicopathologic disease characterized by symptoms of esophageal dysfunction accompanied by an eosinophil-predominant esophageal inflammation that occurs in the absence of other causes of esophageal eosinophilia. Classic symptoms in adults include dysphagia to solids and food bolus impaction but a variety of other symptoms are also encountered. Despite the increasing awareness of EoE among practicing physicians, a long delay from onset of symptoms to diagnosis remains a problem in this disease.

Keywords: Dysphagia; Endoscopy; Eosinophilic esophagitis; Esophageal eosinophilia; Gastroesophageal reflux disease; Narrow-caliber esophagus; PPI-responsive esophageal eosinophilia.