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Comment
. 2014 May 8;157(4):765-7.
doi: 10.1016/j.cell.2014.04.025.

Proliferation at the heart of preadolescence

Nathan J Palpant  1 , Charles E Murry  2
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Proliferation at the heart of preadolescence

Nathan J Palpant et al. Cell. .
Free article

Abstract

Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for congenital and acquired heart diseases.

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