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doi: 10.1016/j.cell.2014.04.026.
Deciphering functions of branched ubiquitin chains
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- PMID: 24813601
- DOI: 10.1016/j.cell.2014.04.026
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Comment
Deciphering functions of branched ubiquitin chains
Cell.
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Abstract
The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Enhanced protein degradation by branched ubiquitin chains.Cell. 2014 May 8;157(4):910-21. doi: 10.1016/j.cell.2014.03.037. Cell. 2014. PMID: 24813613 Free PMC article.
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