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Comment
. 2014 May 8;157(4):767-9.
doi: 10.1016/j.cell.2014.04.026.

Deciphering functions of branched ubiquitin chains

Jaime López-Mosqueda  1 , Ivan Dikic  2
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Deciphering functions of branched ubiquitin chains

Jaime López-Mosqueda et al. Cell. .
Free article

Abstract

The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.

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