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Review
. 2015 Jan 25;32(1):229-35.
doi: 10.1016/j.nbt.2014.04.008. Epub 2014 May 9.

Synthetic mRNAs for manipulating cellular phenotypes: an overview

Elgar Susanne Quabius  1 , Guido Krupp  2
Affiliations
Free article
Review

Synthetic mRNAs for manipulating cellular phenotypes: an overview

Elgar Susanne Quabius et al. N Biotechnol. .
Free article

Abstract

Availability of high quality synthetic mRNAs (syn-mRNAs) has enabled progress in their applications. Important structural features and quality requirements are discussed. Developments in the application of mRNA-mediated manipulation of cells are presented (i) mRNA-directed expression of antigens in dendritic cells for vaccination projects in oncogenesis, infectious disease and allergy prevention; (ii) reprogramming of human fibroblasts to induced pluripotent stem cells with their subsequent differentiation to the desired cell type; (iii) applications in gene therapy.

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