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. 1989 Nov;80(11):1024-7.
doi: 10.1111/j.1349-7006.1989.tb02253.x.

Gene expression of placental glutathione S-transferase in hereditary hepatitis and spontaneous hepatocarcinogenesis of LEC strain rats

R Masuda  1 , M C Yoshida, M Sasaki
Affiliations

Gene expression of placental glutathione S-transferase in hereditary hepatitis and spontaneous hepatocarcinogenesis of LEC strain rats

R Masuda et al. Jpn J Cancer Res. 1989 Nov.

Abstract

Liver tissues of LEC rats, which develop fulminant hepatitis and hepatocellular carcinoma (hepatoma), were examined by Northern blot analysis using a cDNA probe of rat placental glutathione S-transferase (GST-P). GST-P gene expression was observed not only during hepatocarcinogenesis but also in fulminant hepatitis before development of chronic hepatitis and hepatoma in LEC rats. Cholangiofibrosis in LEC rats also showed high GST-P expression. A transplantable cell line derived from spontaneous LEC hepatoma exhibited a remarkably high expression. By contrast, very weak expression was observed in the livers of young LEC rats before development of hepatitis and control strain rats. Thus, spontaneous hepatic lesions in LEC rats may provide a new clue to elucidate the mechanism of GST-P gene expression.

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References

    1. ) Sasaki , M. , Yoshida , M. C. , Kagami , K. , Takeichi , N. , Kobayashi , H. , Dempo , K , and Mori , M.Spontaneous hepatitis in an inbred strain of Long‐Evans rats . Rat News Lett. , 14 , 4 – 6 ( 1985. ).
    1. ) Yoshida , M. C. , Masuda , R. , Sasaki , M. , Takeichi , N. , Kobayashi , H. , Dempo , K , and Mori , M.New mutation causing hereditary hepatitis in the laboratory rat . J. Hered. , 78 , 361 – 365 ( 1987. ). - PubMed
    1. ) Masuda , R. , Yoshida , M. C. , Sasaki , M. , Dempo , K. and Mori , M.Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene . Lab. Anim. , 22 , 166 – 169 ( 1988. ). - PubMed
    1. ) Masuda , R. , Yoshida , M. C. , Sasaki , M. , Dempo , K. and Mori , M.High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis . Jpn. J. Cancer Res. , 79 , 828 – 835 ( 1988. ). - PMC - PubMed
    1. ) Kitahara , A. , Satoh , K. , Nishimura , K. , Ishikawa , T. , Ruike , K. , Sato , K. , Tsuda , H. and Ito , N.Changes in molecular forms of rat hepatic glutathione S‐transferase during chemical hepatocarcinogenesis . Cancer Res. , 44 , 2698 – 2703 ( 1984. ). - PubMed

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