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Case Reports
. 2014 Mar 15;7(4):1792-5.
eCollection 2014.

Small cell type neuroendocrine carcinoma colliding with squamous cell carcinoma at esophagus

Luoluo Yang  1 , Xun Sun  2 , Yabin Zou  2 , Xiangwei Meng  1
Affiliations
Case Reports

Small cell type neuroendocrine carcinoma colliding with squamous cell carcinoma at esophagus

Luoluo Yang et al. Int J Clin Exp Pathol. .

Abstract

Collision tumor is an extremely rare tumor which defined as the concrescence of two distinct primaries neoplasms. We report here a case of collision tumor at lower third esophagus composed of small cell type neuroendocrine carcinoma (NEC), which is an very rare, highly aggressive and poorly prognostic carcinoma and squamous cell carcinoma (SqCC). In our case, pathologically, the small cell carcinoma display the characteristic of small, round, ovoid or spindle-shaped tumor cells with scant cytoplasm, which colliding with a moderately differentiated squamous cell carcinoma. Immunohistochemical staining demonstrated positive activities for CD56, synaptophysin, 34βE12, CK 5/6, ki-67 (70%-80%), but negative for CD99, chromogranin A, and TTF-1. Accurate diagnosis was made base on these findings.

Keywords: Collision tumor; esophagus; neuroendocrine carcinoma; small cell type; squamous cell carcinoma.

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Figures

Figure 1
Figure 1
H&E Staining findings. The esophageal neoplasm was found to consist of two distinct lesions: small cell type NEC on left and SqCC on right in low-power view (A, ×40). Two components were separated by fibrocollagenous tissue (B, ×40). In the high-power view of (C) small cell type NEC and (D) SqCC (×400).
Figure 2
Figure 2
Immunohistochemical staining results. Positive for CD56 and Syn indicate small cell type NEC (A and B, ×40). Stains show a positive reaction in 34βE12, CK5/6, which identify SqCC (C and D, ×40). Strong positive for ki-67 (70%-80%, E, ×40). Magnifying views of A to E (F-J, ×400).
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