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Review
. 2014 Oct;37(5):1779-88.
doi: 10.1007/s10753-014-9908-z.

Therapeutic potential of HO-1 in autoimmune diseases

Bao-Zhu Li  1 , Biao Guo, Hai-Yan Zhang, Juan Liu, Sha-Sha Tao, Hai-Feng Pan, Dong-Qing Ye
Affiliations
Review

Therapeutic potential of HO-1 in autoimmune diseases

Bao-Zhu Li et al. Inflammation. 2014 Oct.

Abstract

Heme oxygenase-1 (HO-1), the inducible isoform of heme oxygenase (HO), has raised a lot of concerns in recent years due to its multiple functions. HO-1 was found to be a pivotal cytoprotective, antioxidant, anti-apoptotic, immunosuppressive, as well as anti-inflammatory molecule. Recent studies have clarified its significant functions in many diseases with substantial findings. In autoimmune diseases, HO-1 may have promising therapeutic potential. Here, we briefly reviewed recent advances in this field, aiming at hopefully exploring the potential therapeutic roles of HO-1, and design HO-1-based strategies for the treatment of autoimmune diseases.

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