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Review
. 2014 May 6:20:19.
doi: 10.1186/1678-9199-20-19. eCollection 2014.

Septic arthritis: immunopathogenesis, experimental models and therapy

Priscila Maria Colavite  1 , Alexandrina Sartori  1
Affiliations
Review

Septic arthritis: immunopathogenesis, experimental models and therapy

Priscila Maria Colavite et al. J Venom Anim Toxins Incl Trop Dis. .

Abstract

Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included.

Keywords: Mice; Septic arthritis; Staphylococcus aureus.

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Figures

Figure 1
Figure 1
Clinical score 2 and corresponding histopathological analyses in a hind paw from a C57BL/6 mouse infected with enterotoxin C producer S. aureus strain. (a’) normal mouse; (b’) mouse with arthritis. (c’, d’) Histopathological micrographics are shown with 10x magnification. JC: joint cavity; C: cartilage; B: bone; BE: bone erosion; CE: cartilage erosion; P: pannus formation and IC: inflammatory cells.
Figure 2
Figure 2
Schematic outline of the parameters that are most frequently analyzed in the murine SA experimental model.
See this image and copyright information in PMC

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