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Review
. 2014 May 12;25(5):560-2.
doi: 10.1016/j.ccr.2014.04.019.

Focal gains of VEGFA: candidate predictors of sorafenib response in hepatocellular carcinoma

Josep M Llovet  1
Affiliations
Review

Focal gains of VEGFA: candidate predictors of sorafenib response in hepatocellular carcinoma

Josep M Llovet. Cancer Cell. .

Abstract

Focal amplifications in 6p21 containing the VEGFA locus occur in 7%-10% of hepatocellular carcinoma (HCC). A recent paper describes how VEGF-A stimulates paracrine secretion of hepatocyte growth factor by stromal cells, which induces tumor progression. HCC patients with VEGFA amplification are distinctly sensitive to sorafenib.

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