14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

Maria Laura Bertolaccini¹, Olga Amengual², Laura Andreoli³, Tatsuya Atsumi², Cecilia B Chighizola⁴, Ricardo Forastiero⁵, Philip de Groot⁶, Gabriella Lakos⁷, Marc Lambert⁸, Pierluigi Meroni⁹, Thomas L Ortel¹⁰, Michelle Petri¹¹, Anisur Rahman¹², Robert Roubey¹³, Savino Sciascia¹⁴, Melissa Snyder¹⁵, Anne E Tebo¹⁶, Angela Tincani³, Rohan Willis¹⁷

Affiliations

¹ Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, London, UK. Electronic address: maria.bertolaccini@kcl.ac.uk.
² Department of Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
³ Department of Clinical and Experimental Sciences, University of Brescia, Italy; Rheumatology and Clinical Immunology Unit, Spedali Civili, Brescia, Italy.
⁴ Division of Rheumatology, Department of Clinical Sciences and Community Health, University of Milan, Italy; Experimental Laboratory of Immunorheumatology, Istituto Auxologico Italiano, Milan, Italy.
⁵ Department of Physiology, Favaloro University, Division of Hematology, Thrombosis and Haemostasis, University Hospital, Favaloro Foundation, Buenos Aires, Argentina.
⁶ Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands.
⁷ INOVA Diagnostics, San Diego, CA, USA.
⁸ Service de Médecine Interne, Hôpital Claude-Huriez, Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
⁹ Experimental Laboratory of Immunorheumatology, Istituto Auxologico Italiano, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Italy.
¹⁰ Clinical Coagulation Laboratory, Laboratory-Based Research, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
¹¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹² Centre for Rheumatology, Division of Medicine University College London, London, UK.
¹³ Division of Rheumatology, Allergy, and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁴ Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, London, UK.
¹⁵ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
¹⁶ Associated Regional and University Pathologists (ARUP) Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
¹⁷ Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.

PMID: 24824074
DOI: 10.1016/j.autrev.2014.05.001

Review

14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

Maria Laura Bertolaccini et al. Autoimmun Rev. 2014 Sep.

. 2014 Sep;13(9):917-30.

doi: 10.1016/j.autrev.2014.05.001. Epub 2014 May 10.

Authors

Affiliations

¹ Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, London, UK. Electronic address: maria.bertolaccini@kcl.ac.uk.
² Department of Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
³ Department of Clinical and Experimental Sciences, University of Brescia, Italy; Rheumatology and Clinical Immunology Unit, Spedali Civili, Brescia, Italy.
⁴ Division of Rheumatology, Department of Clinical Sciences and Community Health, University of Milan, Italy; Experimental Laboratory of Immunorheumatology, Istituto Auxologico Italiano, Milan, Italy.
⁵ Department of Physiology, Favaloro University, Division of Hematology, Thrombosis and Haemostasis, University Hospital, Favaloro Foundation, Buenos Aires, Argentina.
⁶ Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands.
⁷ INOVA Diagnostics, San Diego, CA, USA.
⁸ Service de Médecine Interne, Hôpital Claude-Huriez, Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
⁹ Experimental Laboratory of Immunorheumatology, Istituto Auxologico Italiano, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Italy.
¹⁰ Clinical Coagulation Laboratory, Laboratory-Based Research, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
¹¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹² Centre for Rheumatology, Division of Medicine University College London, London, UK.
¹³ Division of Rheumatology, Allergy, and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁴ Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, London, UK.
¹⁵ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
¹⁶ Associated Regional and University Pathologists (ARUP) Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
¹⁷ Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.

PMID: 24824074
DOI: 10.1016/j.autrev.2014.05.001

Abstract

Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).

Keywords: Antiprothrombin antibodies; Domain I; IgA; Lupus anticoagulant; Risk; aCL.

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14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

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14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

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