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Editorial
. 2014 Sep;166(5):631-3.
doi: 10.1111/bjh.12940. Epub 2014 May 14.

DiagnoSTic assays for heparin-induced thrombocytopenia

Elizabeth E Gardiner  1 , Robert K Andrews, Adam Cuker
Affiliations
Editorial

DiagnoSTic assays for heparin-induced thrombocytopenia

Elizabeth E Gardiner et al. Br J Haematol. 2014 Sep.
No abstract available

Keywords: heparin-induced thrombocytopenia; thrombocytopenia; thrombosis.

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Figures

Figure 1
Figure 1
Factors contributing to the onset of heparin-induced thrombocytopenia (HIT) and the utility of currently available rapid diagnostic assays to monitor HIT. Patients suffering trauma and surgery patients are at greatest risk of developing HIT. Rapid diagnostic assays for HIT mainly focus on identification and, in some cases, quantification of heparin-dependent autoantibodies with limited utility in assessing other patient-specific and platelet-related aspects of HIT that contribute to HIT pathogenesis. The 4T and HIT Expert Probability (HEP) score reflect the pre-test probability of HIT and can be rapidly determined based on criteria involving platelet count and clinical observations. Future rapid tests could also potentially combine rapid immunoassays for HIT-related antibodies with additional practical read-outs of other contributing factors, for example, antibody-induced platelet activation markers (Gardiner et al 2008), FcγRIIa-dependent responses (Cuker et al 2013, Nazi et al 2013) and/or other ‘next-generation’ tests reflecting the patients’ individual risk of developing HIT.
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