doi: 10.1016/0143-4179(89)90042-5.
Involvement of endopeptidase-24.11 in degradation of substance P by glioma cells
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- PMID: 2482461
- DOI: 10.1016/0143-4179(89)90042-5
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Involvement of endopeptidase-24.11 in degradation of substance P by glioma cells
Neuropeptides.
1989 Oct.
Abstract
C6 of rat glioma cells and their plasma membranes degrade substance P (SP). The degradation, occurring mainly through the cleavage of the Gln6-Phe7, Phe7-Phe8, and Gly9-Leu10 bonds, was strongly inhibited by phosphoramidon. Endopeptidase-24.11 (EC 3.4.24.11) purified from C6 cell membranes also cleaved SP at the same three peptide bonds in a manner sensitive to phosphoramidon. Thus, the degradation of SP by glioma cells and their membranes seems to be mediated by the action of endopeptidase-24.11.
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