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Review
. 2014 Jul;9(4):346-54.
doi: 10.1097/COH.0000000000000065.

Cardiovascular disease risk in an aging HIV population: not just a question of biology

Kaku So-Armah  1 , Matthew S Freiberg
Affiliations
Review

Cardiovascular disease risk in an aging HIV population: not just a question of biology

Kaku So-Armah et al. Curr Opin HIV AIDS. 2014 Jul.

Abstract

Purpose of review: The objective of this review is to appraise recently published literature that describes the relationship between HIV, biologic and environmental risk factors, and cardiovascular disease (CVD) risk with particular emphasis on the aging HIV population and to demonstrate that these biologic and environmental factors may interact to increase the risk of CVD in the HIV population.

Recent findings: The mechanisms linking HIV and CVD are multifactorial and encompass biological and 'environmental' modalities including multimorbid conditions that co-occur with HIV, immunologic alterations associated with HIV, polypharmacy (which affects adherence and increases likelihood of adverse drug-drug interactions) and healthcare disparities in CVD risk reduction by HIV status.

Summary: Data regarding optimal treatment strategies that balance immunological restoration and CVD risk reduction are needed.

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Conflict of interest statement

Conflict of interest

There are no conflicts of interest.

Figures

Figure 1
Figure 1
People aged 50 years or older, as a percentage of all adults 15 years or older living with HIV, by region, 1995–2012 (Image from UNAIDS https://www.un.org/apps/news//story.asp?NewsID=46393&Cr=hiv&Cr1=aids#collapseTwo).
Figure 2
Figure 2
Mechanisms of CVD in HIV
See this image and copyright information in PMC

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References

Annotated bibliography

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