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Review
. 2014 Jul;16(7):452.
doi: 10.1007/s11920-014-0452-1.

Schizotypal personality disorder: a current review

Daniel R Rosell  1 , Shira E Futterman, Antonia McMaster, Larry J Siever
Affiliations
Review

Schizotypal personality disorder: a current review

Daniel R Rosell et al. Curr Psychiatry Rep. 2014 Jul.

Abstract

The study of schizotypal personality disorder (SPD) is important clinically, as it is understudied, challenging to treat, often under-recognized or misdiagnosed, and associated with significant functional impairment. SPD also represents an intermediate schizophrenia-spectrum phenotype, and therefore, can provide a better understanding of the genetics, pathogenesis, and treatment of related psychotic illnesses. In this review we discuss recent findings of SPD related to epidemiology and functional impairment, heritability and genetics, working memory and cognitive impairments, social-affective disturbances, and neurobiology. Additionally, we examine the challenges associated with treating patients with SPD, as well as clinical recommendations. Finally, we address future directions and areas in need of further exploration.

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Conflict of interest statement

Compliance with Ethics Guidelines: Conflict of Interest: Daniel R. Rosell has received support for travel and payment from writing or reviewing manuscript from the Department of Veterans Affairs.

Shira E. Futterman has received a grant from the National Institute of Mental Health.

Antonia McMaster has received a grant from the National Institute of Mental Health.

Larry J. Siever has received grants and travel support from the National Institute of Mental Health and the Department of Veterans Affairs. He also received travel support from the Mental Illness Research, Education and Clinical Centers. Dr. Siever also has receive payment for writing or reviewing manuscripts from the Department of Veterans Affairs, the Mental Illness Research, Education and Clinical Centers, and Mount Sinai.

References

    1. Hummelen B, Pedersen G, Karterud S. Some suggestions for the DSM-5 schizotypal personality disorder construct. Compr Psychiatry. 2012;53:341–349. This study comprehensively examines the factor structure and psychometric properties of SPD criteria among a large clinical population of personality disordered patients assessed by structured interview. - PubMed
    1. Lien YJ, Tsuang HC, Chiang A, et al. The multidimensionality of schizotypy in nonpsychotic relatives of patients with schizophrenia and its applications in ordered subsets linkage analysis of schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1–9. In a large population of non-psychotic relatives of schizophrenia patients, a four-factor schizotypy model was confirmed, and these factors were found to be linked with specific chromosomal regions. - PubMed
    1. Cohen AS, Matthews RA, Najolia GM, Brown LA. Toward a more psychometrically sound brief measure of schizotypal traits: introducing the SPQ-Brief Revised. J Pers Disord. 2010;24:516–537. - PubMed
    1. Pulay AJ, Stinson FS, Dawson DA, et al. Prevalence, correlates, disability, and comorbidity of DSM-IV schizotypal personality disorder: results from the wave 2 national epidemiologic survey on alcohol and related conditions. Prim Care Companion J Clin Psychiatry. 2009;11:53–67. - PMC - PubMed
    1. McClure MM, Harvey PD, Bowie CR, Iacoviello B, Siever LJ. Functional outcomes, functional capacity, and cognitive impairment in schizotypal personality disorder. Schizophr Res. 2013;144:146–150. This studies establishes the importance of working memory/cognitive dysfunction in determining functional outcomes in SPD. - PMC - PubMed

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