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. 2014 May 14;9(5):e96013.
doi: 10.1371/journal.pone.0096013. eCollection 2014.

Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline

Moeko Noguchi-Shinohara  1 , Sohshi Yuki  1 , Chiaki Dohmoto  1 , Yoshihisa Ikeda  1 , Miharu Samuraki  1 , Kazuo Iwasa  1 , Masami Yokogawa  2 , Kimiko Asai  3 , Kiyonobu Komai  4 , Hiroyuki Nakamura  5 , Masahito Yamada  1
Affiliations

Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline

Moeko Noguchi-Shinohara et al. PLoS One. .

Abstract

Our objective was to determine whether the consumption of green tea, coffee, or black tea influences the incidence of dementia and mild cognitive impairment (MCI) in older people. We conducted a population-based prospective study with Japanese residents aged >60 years from Nakajima, Japan (the Nakajima Project). Participants received an evaluation of cognitive function and blood tests. The consumption of green tea, coffee, and black tea was also evaluated at baseline. Of 723 participants with normal cognitive function at a baseline survey (2007-2008), 490 completed the follow up survey in 2011-2013. The incidence of dementia during the follow-up period (mean ± SD: 4.9 ± 0.9 years) was 5.3%, and that of MCI was 13.1%. The multiple-adjusted odds ratio for the incidence of overall cognitive decline (dementia or MCI) was 0.32 (95% CI: 0.16-0.64) among individuals who consumed green tea every day and 0.47 (95% CI: 0.25-0.86) among those who consumed green tea 1-6 days per week compared with individuals who did not consume green tea at all. The multiple-adjusted odds ratio for the incidence of dementia was 0.26 (95% CI: 0.06-1.06) among individuals who consumed green tea every day compared with those who did not consume green tea at all. No association was found between coffee or black tea consumption and the incidence of dementia or MCI. Our results indicate that green tea consumption is significantly associated with reduced risk of cognitive decline, even after adjustment for possible confounding factors.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

References

    1. Levites Y, Weinreb O, Maor G, Youdim MBH, Mandel S (2001) Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 377: 1073–1082. - PubMed
    1. Choi YT, Jung CH, Lee SR, Bae JH, Baek WK, et al. (2001) The green tea polyphenol (-)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons. Life Sci 70: 603–614. - PubMed
    1. Levites Y, Amit T, Mandel S, Youdim MBH (2003) Neuroprotection and neurorescue against Aβ toxicity and PKC-dependent release of nonamyloidgenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J 17: 952–954. - PubMed
    1. Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, et al. (2003) Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem 87: 172–181. - PubMed
    1. Rezai-Zadeh K, Arendash GW, Hou H, Fernandez F, Jensen M, et al. (2008) Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res 1214: 177–187. - PubMed

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