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. 2014 Jun 23;53(26):6692-5.
doi: 10.1002/anie.201403878. Epub 2014 May 14.

Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamides

Youqian Deng  1 , Wei Gong, Jian He, Jin-Quan Yu
Affiliations

Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamides

Youqian Deng et al. Angew Chem Int Ed Engl. .

Abstract

Diverse 4-aryl-2-quinolinones are prepared from propionamides in one pot by ligand-promoted triple sequential C-H activation reactions and a stereospecific Heck reaction. In these cascade reactions, three new C-C bonds and one C-N bond are formed to rapidly build molecular complexity from propionic acid.

Keywords: C-H activation; amidation; arylation; dehydrogenation; quinolinone.

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Figures

Scheme 1
Scheme 1
Biologically active 4-aryl-2-quinolinones.
Scheme 2
Scheme 2
Synthetic applications.
Scheme 3
Scheme 3
Proposed catalytic pathway.
See this image and copyright information in PMC

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