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Review
. 2014 Oct;39(5):457-67.
doi: 10.1111/jcpt.12171. Epub 2014 May 14.

Involvement of neuronal β2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies

Steven J Simmons  1 , Thomas J Gould
Affiliations
Review

Involvement of neuronal β2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies

Steven J Simmons et al. J Clin Pharm Ther. 2014 Oct.

Abstract

What is known and objective: Tobacco smoking remains a major health problem. Nicotine binds to nicotinic acetylcholine receptors (nAChRs), which can cause addiction and withdrawal symptoms upon cessation of nicotine administration. Pharmacotherapies for nicotine addiction target brain alterations that underlie withdrawal symptoms. This review will delineate the involvement of the β2 subunit of neuronal nAChRs in nicotine reward and in generating withdrawal symptoms to better understand the efficacy of smoking cessation pharmacotherapies.

Comment: Chronic nicotine desensitizes and upregulates β2 subunit-containing nAChRs, and the prolonged upregulation of receptors may underlie symptoms of withdrawal. Experimental research has demonstrated that the β2 subunit of neuronal nAChRs is necessary for generating nicotine reward and withdrawal symptoms.

What is new and conclusion: Smoking cessation pharmacotherapies act on β2 subunit-containing nAChRs to reduce nicotine reward and withdrawal symptom severity.

Keywords: nicotine reward; nicotine withdrawal; nicotinic acetylcholine receptor; smoking cessation; β2 subunit.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflict of interest.

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