NK Cells during Dengue Disease and Their Recognition of Dengue Virus-Infected cells
- PMID: 24829565
- PMCID: PMC4017149
- DOI: 10.3389/fimmu.2014.00192
NK Cells during Dengue Disease and Their Recognition of Dengue Virus-Infected cells
Abstract
The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunity may be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENV-infected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome. This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.
Keywords: NK cell; NK ligand; NK receptor; dengue; innate immune response.
Figures

Similar articles
-
Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules.mBio. 2017 Aug 1;8(4):e00741-17. doi: 10.1128/mBio.00741-17. mBio. 2017. PMID: 28765218 Free PMC article.
-
HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response.Front Cell Infect Microbiol. 2019 Jul 23;9:268. doi: 10.3389/fcimb.2019.00268. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31396492 Free PMC article.
-
Mass Cytometry Analysis of the NK Cell Receptor-Ligand Repertoire Reveals Unique Differences between Dengue-Infected Children and Adults.Immunohorizons. 2020 Oct 16;4(10):634-647. doi: 10.4049/immunohorizons.2000074. Immunohorizons. 2020. PMID: 33067399 Free PMC article.
-
Control of acute dengue virus infection by natural killer cells.Front Immunol. 2014 May 13;5:209. doi: 10.3389/fimmu.2014.00209. eCollection 2014. Front Immunol. 2014. PMID: 24860571 Free PMC article. Review.
-
Defining the role of NK cells during dengue virus infection.Immunology. 2018 Mar 23;154(4):557-62. doi: 10.1111/imm.12928. Online ahead of print. Immunology. 2018. PMID: 29570783 Free PMC article. Review.
Cited by
-
Development of IgG Mediated Antibody Dependent Cell-mediated Cytotoxicity (ADCC) in the Serum and Genital Mucosa of HIV Seroconverters.J AIDS Clin Res. 2015 Jul;6(7):479. doi: 10.4172/2155-6113.1000479. Epub 2015 Jul 9. J AIDS Clin Res. 2015. PMID: 26798561 Free PMC article.
-
Antiviral Role of Phenolic Compounds against Dengue Virus: A Review.Biomolecules. 2020 Dec 24;11(1):11. doi: 10.3390/biom11010011. Biomolecules. 2020. PMID: 33374457 Free PMC article. Review.
-
Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients.PLoS Negl Trop Dis. 2016 Mar 3;10(3):e0004499. doi: 10.1371/journal.pntd.0004499. eCollection 2016 Mar. PLoS Negl Trop Dis. 2016. PMID: 26938618 Free PMC article.
-
Immunopathology of Renal Tissue in Fatal Cases of Dengue in Children.Pathogens. 2022 Dec 15;11(12):1543. doi: 10.3390/pathogens11121543. Pathogens. 2022. PMID: 36558877 Free PMC article.
-
Characterization of Dendritic Cell-Derived Extracellular Vesicles During Dengue Virus Infection.Front Microbiol. 2018 Aug 6;9:1792. doi: 10.3389/fmicb.2018.01792. eCollection 2018. Front Microbiol. 2018. PMID: 30131785 Free PMC article.
References
-
- Anon. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: World Health Organization and the Special Programme for Research and Training in Tropical diseases; (2009). p. 25–8
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials