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Case Reports
. 2014 Apr 27;6(4):77-9.
doi: 10.4240/wjgs.v6.i4.77.

Neuroendocrine carcinoma of the stomach: A case report

Sang Hyun Kang  1 , Kwang Hee Kim  1 , Sang Hyuk Seo  1 , Min Sung An  1 , Tae Kwun Ha  1 , Ha Kyung Park  1 , Ki Beom Bae  1 , Chang Soo Choi  1 , Sang Hun Oh  1 , Young Kil Choi  1
Affiliations
Case Reports

Neuroendocrine carcinoma of the stomach: A case report

Sang Hyun Kang et al. World J Gastrointest Surg. .

Abstract

Neuroendocrine carcinoma (NEC) is a rare tumor, comprising < 1% of stomach cancers. A 55-year-old woman was referred to our hospital with biopsy-proven gastric cancer. A shallow ulcerative lesion was detected in the lesser curvature of the lower body. It was suspected to be early gastric cancer IIA + IIC type. Thus, endoscopic submucosal dissection was performed. She was subsequently diagnosed with NEC, which is aggressive and carries a poor prognosis. We conducted a radical resection and a laparoscopic-assisted distal gastrectomy. The tumor had infiltrated the subserosal layer and 6/42 lymph nodes were involved. The mitotic index was 16/10 high power fields and the Ki-67 labeling index was 26%-50%. The final diagnosis of NEC was made according to the World Health Organization 2010 criteria. She was suspected of having jumping metastasis to the proximal margin. The patient was treated with an oral anticancer drug (5-flurouracil based drug) for 2 years. The patient has been followed up for 3 years without recurrence.

Keywords: Gastrectomy; Ki-67; Mitosis; Neuroendocrine carcinoma; Prognosis.

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Figures

Figure 1
Figure 1
Endoscopic findings. Ulcerative lesion in the lesser curvature of the lower body.
Figure 2
Figure 2
Endoscopic submucosal dissection specimen. A hypercellular lesion was detected in the mucosa and submucosal layers.
Figure 3
Figure 3
Laparoscopic assisted distal gastrectomy specimen. The ulcerative lesion due to mucosal detachment after endoscopic submucosal dissection is distinguished from normal mucosa (right side). Fibrosis was observed in the submucosal layer and a hypercellular lesion that was the same as the endoscopic submucosal dissection specimen in the muscle and subserosa layers.
See this image and copyright information in PMC

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