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Review
. 2014:2014:631756.
doi: 10.1155/2014/631756. Epub 2014 Apr 14.

Gabapentin in acute postoperative pain management

Connie Y Chang  1 , Chaitanya K Challa  1 , Janki Shah  1 , Jean Daniel Eloy  1
Affiliations
Review

Gabapentin in acute postoperative pain management

Connie Y Chang et al. Biomed Res Int. 2014.

Abstract

Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ -aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative pain following spinal surgery and hysterectomy. This study reviews five aspects of gabapentin: (1) chemical and structural characteristics; (2) pharmacokinetics and pharmacodynamics; (3) application in acute pain management; (4) adverse effects; and (5) drug safety. Overall, gabapentin has been reported to be a safe and efficacious drug for the treatment of postoperative pain.

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References

    1. Maneuf YP, Gonzalez MI, Sutton KS, Chung FZ, Pinnock RD, Lee K. Cellular and molecular action of the putative GABA-mimetic, gabapentin. Cellular and Molecular Life Sciences. 2003;60(4):742–750. - PMC - PubMed
    1. Gidal B, Billington R. New and emerging treatment options for neuropathic pain. The American Journal of Managed Care. 2006;12:S269–S278. - PubMed
    1. Taylor CP, Gee NS, Su TZ, et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Research. 1998;29(3):233–249. - PubMed
    1. Dahl JB, Mathiesen O, Møiniche S. ‘Protective premedication’: an option with gabapentin and related drugs? A review of gabapentin and pregabalin in the treatment of post-operative pain. Acta Anaesthesiologica Scandinavica. 2004;48(9):1130–1136. - PubMed
    1. Sills GJ. Not another gabapentin mechanism! Epilepsy Currents. 2005;5(2):75–77. - PMC - PubMed

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