Comparative Study
Enhanced induction of plasma interferon after subcutaneous administration in rabbits of poly ICLC with albumin
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- PMID: 2483023
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Comparative Study
Enhanced induction of plasma interferon after subcutaneous administration in rabbits of poly ICLC with albumin
J Biol Regul Homeost Agents.
1989 Jul-Sep.
Abstract
Intravenous administration of poly ICLC in rabbits yields very high plasma interferon (IFN) levels; dosages from 250 to 1000 micrograms/kg body weight are very toxic. Subcutaneous administration of poly ICLC together with a high concentration of human serum albumin potentiates the inducer activity in comparison to poly ICLC in saline. Finally, a dosage of 50 micrograms of poly ICLC in 12% serum albumin is more effective as an IFN inducer than other dosages.
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