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. 2014 Jun;33(6):e158-61.
doi: 10.1097/INF.0000000000000238.

The quest for the best metric of antibiotic use and its correlation with the emergence of fluoroquinolone resistance in children

Lucia Rose  1 , Marissa M Coulter, Shannon Chan, Jobayer Hossain, M Cecilia Di Pentima
Affiliations

The quest for the best metric of antibiotic use and its correlation with the emergence of fluoroquinolone resistance in children

Lucia Rose et al. Pediatr Infect Dis J. 2014 Jun.

Abstract

We evaluated the correlation between fluoroquinolone use, measured by doses administered and days of therapy, with the emergence of ciprofloxacin and levofloxacin resistance among Gram-negative bacilli infections in children hospitalized at one pediatric center between April 2001 and March 2009. Both metrics and drug resistance were highly correlated.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Trends in ciprofloxacin-resistant (blue squares) and levofloxacin-resistant (red dots) Gram-negative bacilli infections among hospitalized children per 1000 admissions, and ciprofloxacin and levofloxacin use expressed as doses administered and days of therapy per 1000 patient-days, Alfred I. duPont Hospital for Children 2001–2009. Sloping of ciprofloxacin resistance (blue line) and levofloxacin resistance (red line) overtime are shown
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References

    1. Linder JA, Huang ES, Steinman MA, et al. Fluoroquinolone prescribing in the United States: 1995 to 2002. Am J Med. 2005;118:259–268. - PubMed
    1. Committee on Infectious Diseases. The use of systemic fluoroquinolones. Pediatrics. 2006;118:1287–1292. - PubMed
    1. Meier S, Weber R, Zbinden R, et al. Extended-spectrum β-lactamase-producing Gram-negative pathogens in community-acquired urinary tract infections: an increasing challenge for antimicrobial therapy. Infection. 2011;39:333–340. - PubMed
    1. Livermore DM, Hope R, Brick G, et al. Non-susceptibility trends among Enterobacteriaceae from bacteraemias in the UK and Ireland, 2001–06. J Antimicrob Chemother. 2008;62(suppl 2):ii41–ii54. - PubMed
    1. Dellit TH, Owens RC, McGowan JE, Jr, et al. Infectious Diseases Society of America; Society for Healthcare Epidemiology of America. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44:159–177. - PubMed

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