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Review
. 2014 May 14;19(5):6080-105.
doi: 10.3390/molecules19056080.

Issues and prospects of microRNA-based biomarkers in blood and other body fluids

John R Chevillet  1 , Inyoul Lee  1 , Hilary A Briggs  2 , Yuqing He  3 , Kai Wang  4
Affiliations
Review

Issues and prospects of microRNA-based biomarkers in blood and other body fluids

John R Chevillet et al. Molecules. .

Abstract

Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities.

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Conflict of interest statement

The authors declare no conflict of interest.

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