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. 2013 Jan 14;2(1):107-41.
doi: 10.3390/biology2010107.

PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation

Erika Di Zazzo  1 , Caterina De Rosa  2 , Ciro Abbondanza  3 , Bruno Moncharmont  4
Affiliations

PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation

Erika Di Zazzo et al. Biology (Basel). .

Abstract

PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats. Experimental evidence has shown that the PRDM proteins play an important role in gene expression regulation, modifying the chromatin structure either directly, through the intrinsic methyltransferase activity, or indirectly through the recruitment of chromatin remodeling complexes. PRDM proteins have a dual action: they mediate the effect induced by different cell signals like steroid hormones and control the expression of growth factors. PRDM proteins therefore have a pivotal role in the transduction of signals that control cell proliferation and differentiation and consequently neoplastic transformation. In this review, we describe pathways in which PRDM proteins are involved and the molecular mechanism of their transcriptional regulation.

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Figures

Figure 1
Figure 1
PRDM2 is an estrogen receptor co-activator.
Figure 2
Figure 2
Prdm4/SC-1 (Schwann Cell factor 1) provides a downstream transducer for the effects of nerve growth factor (NGF) through the p75 neurotrophin receptor and forms an epigenetic regulatory complex with Prmt5 that probably maintains the “stem-like” cellular state of a NSC.
Figure 3
Figure 3
PRDM5 regulates the Wnt/β-catenin signaling in normal cells and in cancer cells.
Figure 4
Figure 4
Notch-Hes pathway controls the expression of Prdm8 and Prdm16.
Figure 5
Figure 5
PRDM16 modulates TGF-β signaling.
See this image and copyright information in PMC

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