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Case Reports
. 2014 Nov;25(11):1597-9.
doi: 10.1007/s00192-014-2427-5. Epub 2014 May 16.

Collagen scaffold: a treatment for large mesh exposure following vaginal prolapse repair

Marianna Alperin  1
Affiliations
Case Reports

Collagen scaffold: a treatment for large mesh exposure following vaginal prolapse repair

Marianna Alperin. Int Urogynecol J. 2014 Nov.

Abstract

Transvaginal repair with mesh of pelvic organ prolapse (POP) provides women with the durability of a synthetic graft using the less-invasive route of vaginal surgery. However, morbidities such as mesh exposures are common and challenging to manage. Small intestinal submucosa (SIS) is a naturally occurring collagen matrix derived from porcine intestine. It contains growth factors and cytokines that promote healing of damaged tissue. This case report describes a large vaginal mesh exposure due to necrosis of the full thickness of the anterior vaginal wall. A remarkable and rapid regeneration of vaginal tissue over the exposed mesh was achieved with SIS placement after failure of treatment with vaginal estrogen for >6 months. Collagen scaffold is an effective, rapid, and minimally invasive treatment for large vaginal mesh exposures.

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Conflict of interest statement

Conflict of interest None

Figures

Fig. 1
Fig. 1
Large area of mesh exposure due to necrosis of the full thickness of the anterior vaginal wall, with minimal tissue ingrowth after treatment with vaginal estrogen cream for 6 months
Fig. 2
Fig. 2
a Regenerated anterior vaginal wall tissue completely covering exposed mesh 2 weeks after treatment with a small intestinal submucosal (SIS) graft. b Four weeks after treatment with SIS graft
See this image and copyright information in PMC

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References

    1. Clemons JL, Weinstein M, Guess MK, Alperin M, Moalli P, Gregory WT, et al. Impact of the 2011 FDA transvaginal mesh safety update on AUGS members’ use of synthetic mesh and biologic grafts in pelvic reconstructive surgery. Female Pelvic Med Reconstr Surg. 2013;19(4):191–198. - PubMed
    1. Abed H, Rahn DD, Lowenstein L, Balk EM, Clemons JL, Rogers RG. Incidence and management of graft erosion, wound granulation, and dyspareunia following vaginal prolapse repair with graft materials: a systematic review. Int Urogynecol J. 2011;22(7):789–798. - PubMed
    1. Tijdink MM, Vierhout ME, Heesakkers JP, et al. Surgical management of mesh-related complications after prior pelvic floor reconstructive surgery with mesh. Int Urogynecol J. 2011;22:1395–1404. - PMC - PubMed
    1. Brown BN, Badylak SF. Extracellular matrix as an inductive scaffold for functional tissue reconstruction. Transl Res. 2014;163(4):268–285. - PMC - PubMed
    1. Khong SY, Lam A. Use of Surgisis mesh in the management of polypropylene mesh erosion into the vagina. Int Urogynecol J. 2011;22(1):41–46. - PubMed

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