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Comment
. 2014 May 15;123(20):3060-1.
doi: 10.1182/blood-2014-03-563718.

HSC senescence upon irradiation

Hartmut Geiger  1
Affiliations
Comment

HSC senescence upon irradiation

Hartmut Geiger. Blood. .

Abstract

In this issue of Blood, Shao et al report that a side effect of total body irradiation (TBI) is long-term bone marrow injury and thus dysfunctional hematopoiesis caused by the induction of hematopoietic stem cell (HSC) senescence. Interestingly and unexpectedly, however, this happens in a manner independent of the cell-cycle regulators Ink4a and Arf, which play a major role in senescence in other cell systems.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Comment on

References

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