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Review
. 2014 May 15;6(5):112-20.
doi: 10.4251/wjgo.v6.i5.112.

Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities

Kyle J Napier  1 , Mary Scheerer  1 , Subhasis Misra  1
Affiliations
Review

Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities

Kyle J Napier et al. World J Gastrointest Oncol. .

Abstract

Esophageal cancer is a serious malignancy with regards to mortality and prognosis. It is a growing health concern that is expected to increase in incidence over the next 10 years. Squamous cell carcinoma is the most common histological type of esophageal cancer worldwide, with a higher incidence in developing nations. With the increased prevalence of gastroesophageal reflux disease and obesity in developed nations, the incidence of esophageal adenocarcinoma has dramatically increased in the past 40 years. Esophageal cancer is staged according to the widely accepted TNM system. Staging plays an integral part in guiding stage specific treatment protocols and has a great impact on overall survival. Common imaging modalities used in staging include computed tomography, endoscopic ultrasound and positron emission tomography scans. Current treatment options include multimodality therapy mainstays of current treatment include surgery, radiation and chemotherapy. Tumor markers of esophageal cancer are an advancing area of research that could potentially lead to earlier diagnosis as well as playing a part in assessing tumor response to therapy.

Keywords: Esophageal adenocarcinoma; Esophageal cancer; Esophageal cancer staging; Esophageal squamous cell carcinoma; Surgery.

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References

    1. Lambert R, Hainaut P. The multidisciplinary management of gastrointestinal cancer. Epidemiology of oesophagogastric cancer. Best Pract Res Clin Gastroenterol. 2007;21:921–945. - PubMed
    1. Herszényi L, Tulassay Z. Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci. 2010;14:249–258. - PubMed
    1. Surveillance, Epidemiology, and End Results ProgramTurning. SEER Stat Fact Sheets: Esophageal Cancer. Retrieved November 9, 2013. Available from: http: //seer.cancer. gov/statfacts/html/esoph.html.
    1. Pennathur A, Gibson MK, Jobe BA, Luketich JD. Oesophageal carcinoma. Lancet. 2013;381:400–412. - PubMed
    1. Absi A, Adelstein DJ, Rice T. Esophageal Cancer. 2013. Available from: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hemato...