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. 2011 Fall;4(4):186-91.

A quick look at obesity; the enemy within

Parichehr Hassanzadeh  1
Affiliations

A quick look at obesity; the enemy within

Parichehr Hassanzadeh. Gastroenterol Hepatol Bed Bench. 2011 Fall.

Abstract

Obesity with an increasing prevalence rate worldwide is correlated with multiple comorbidities. Unfortunately, the currently available therapies such as the pharmacotherapy, bariatric surgery or gene-transfer technology are associated with a number of disadvantages including undesirable side effects, poor compliance or transient effectiveness. Therefore, modifications of the lifestyle factors might be of great importance. Recently, neurotrophic factors and their metabotrophic potential in targeted pharmacology against obesity has been the focus of intense research. Meanwhile, because of the complexity and multi-factorial nature of obesity, it will still remain as a challenging medical problem.

Keywords: Brain; Chemical contributors; Obesity; Therapeutic approaches.

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References

    1. Hurt RT, Frazier TH, McClave SA, Kaplan LM. Obesity epidemic: overview, pathophysiology, and the intensive care unit conundrum. J Parenter Enteral Nutr. 2011;35:4S–13S. - PubMed
    1. Kasotakis G, Mittal SK, Sudan R. Combined treatment of symptomatic massive paraesophageal hernia in the morbidly obese. J Soci Lapar Surg. 2011;15:188–192. - PMC - PubMed
    1. Pop-Jordanova N. Psychological characteristics and biofeedback mitigation in preadolescents with eating disorders. Pediatr Int. 2000;42:76–81. - PubMed
    1. Enriori PJ, Sinnayah P, Simonds SE, Garcia Rudaz C, Cowley MA. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci. 2011;31:12189–97. - PMC - PubMed
    1. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573–85. - PubMed

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