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. 2014 Jun 28;50(51):6801-4.
doi: 10.1039/c4cc00447g.

A rational approach for generating cardiac troponin I selective Spiegelmers

Zsuzsanna Szeitner  1 , Gergely Lautner, Szilvia K Nagy, Róbert E Gyurcsányi, Tamás Mészáros
Affiliations

A rational approach for generating cardiac troponin I selective Spiegelmers

Zsuzsanna Szeitner et al. Chem Commun (Camb). .

Abstract

We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum.

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