IL-10 and macrophages orchestrate gut homeostasis

Alberto Mantovani¹, Federica Marchesi²

Affiliations

¹ Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
² Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy.

PMID: 24837099
DOI: 10.1016/j.immuni.2014.04.015

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IL-10 and macrophages orchestrate gut homeostasis

Alberto Mantovani et al. Immunity. 2014.

Free article

. 2014 May 15;40(5):637-9.

doi: 10.1016/j.immuni.2014.04.015.

Authors

Alberto Mantovani¹, Federica Marchesi²

Affiliations

¹ Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
² Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy.

PMID: 24837099
DOI: 10.1016/j.immuni.2014.04.015

Abstract

Macrophages in the gut originate from blood precursors and have distinct functional properties. In this issue of Immunity,Zigmond et al. (2014) and Shouval et al. (2014) report that interleukin-10 drives macrophages to express homeostatic tolerogenic functions, preventing colitis.

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Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Shouval DS, et al. Immunity. 2014 May 15;40(5):706-19. doi: 10.1016/j.immuni.2014.03.011. Epub 2014 May 1. Immunity. 2014. PMID: 24792912 Free PMC article.
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
Zigmond E, Bernshtein B, Friedlander G, Walker CR, Yona S, Kim KW, Brenner O, Krauthgamer R, Varol C, Müller W, Jung S. Zigmond E, et al. Immunity. 2014 May 15;40(5):720-33. doi: 10.1016/j.immuni.2014.03.012. Epub 2014 May 1. Immunity. 2014. PMID: 24792913

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IL-10 and macrophages orchestrate gut homeostasis

Affiliations

IL-10 and macrophages orchestrate gut homeostasis

Authors

Affiliations

Abstract

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Publication types

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Full Text Sources

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Medical