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Review
. 2014 May-Jun;5(3):404-10.
doi: 10.4161/gmic.29232. Epub 2014 May 16.

The effects of gut microbiota on CNS function in humans

Kirsten Tillisch  1
Affiliations
Review

The effects of gut microbiota on CNS function in humans

Kirsten Tillisch. Gut Microbes. 2014 May-Jun.

Abstract

The role of the gastrointestinal microbiota in human brain development and function is an area of increasing interest and research. Preclinical models suggest a role for the microbiota in broad aspects of human health, including mood, cognition, and chronic pain. Early human studies suggest that altering the microbiota with beneficial bacteria, or probiotics, can lead to changes in brain function, as well as subjective reports of mood. As the mechanisms of bidirectional communication between the brain and microbiota are better understood, it is expected that these pathways will be harnessed to provide novel methods to enhance health and treat disease.

Keywords: anxiety; brain-gut axis; depression; microbiota; probiotic.

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Figures

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Figure 1. Potential routes of communication between the microbiota and the brain are shown. Multiple inputs from the periphery can act centrally to modulate mood, pain sensitivity, cognition, and behavior.
See this image and copyright information in PMC

References

    1. Jiménez E, Fernández L, Marín ML, Martín R, Odriozola JM, Nueno-Palop C, Narbad A, Olivares M, Xaus J, Rodríguez JM. Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section. Curr Microbiol. 2005;51:270–4. doi: 10.1007/s00284-005-0020-3. - DOI - PubMed
    1. Wagner CL, Taylor SN, Johnson D. Host factors in amniotic fluid and breast milk that contribute to gut maturation. Clin Rev Allergy Immunol. 2008;34:191–204. doi: 10.1007/s12016-007-8032-3. - DOI - PubMed
    1. Satokari R, Grönroos T, Laitinen K, Salminen S, Isolauri E. Bifidobacterium and Lactobacillus DNA in the human placenta. Lett Appl Microbiol. 2009;48:8–12. doi: 10.1111/j.1472-765X.2008.02475.x. - DOI - PubMed
    1. Al-Asmakh M, Anuar F, Zadjali F, Rafter J, Pettersson S. Gut microbial communities modulating brain development and function. Gut Microbes. 2012;3:366–73. doi: 10.4161/gmic.21287. - DOI - PMC - PubMed
    1. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ. 2013;185:385–94. doi: 10.1503/cmaj.121189. - DOI - PMC - PubMed

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