Structural biology: a 'funny' cyclic dinucleotide receptor
- PMID: 24838168
- DOI: 10.1038/nchembio.1530
Structural biology: a 'funny' cyclic dinucleotide receptor
Abstract
Deciphering the molecular basis of HCN channel regulation by cGMP leads to the serendipitous discovery of cyclic dinucleotides as potent inhibitors of I(f) current in the heart.
Comment on
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Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.Nat Chem Biol. 2014 Jun;10(6):457-62. doi: 10.1038/nchembio.1521. Epub 2014 Apr 28. Nat Chem Biol. 2014. PMID: 24776929
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