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. 2014 Jun 28;12(24):4233-42.
doi: 10.1039/c4ob00175c.

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

Ana I Sánchez  1 , Ricardo Meneses, José M Mínguez, Araceli Núñez, Rafael R Castillo, Fabiana Filace, Carolina Burgos, Juan J Vaquero, Julio Álvarez-Builla, Alvaro Cortés-Cabrera, Federico Gago, Emma Terricabras, Víctor Segarra
Affiliations

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

Ana I Sánchez et al. Org Biomol Chem. .

Abstract

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds.

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