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Review
. 1989;2(3):347-52.
doi: 10.1016/0952-7915(89)90140-4.

Immunity to viruses

A Zurbriggen  1 , R S Fujinami
Affiliations
Review

Immunity to viruses

A Zurbriggen et al. Curr Opin Immunol. 1989.
No abstract available

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References

    1. Schijns V.E., Borman T.H., Schellekens H., Horzinek M.C. Antiviral activity of recombinant rat interferon gamma in immunologically impaired and immunosupressed rats. J Gen Virol. 1989;69:1979–1985. Of interest. - PubMed

    2. IFNγ may directly inhibit virus replication in the cell without stimulation of the immune system.

    1. Maier K., Gabriel P., Koscielniak E., Stierhof Y.-D., Wiedmann K.H., Flehmig B., Vallbracht A. Human gamma interferon production by cytotoxic T lymphocytes sensitized during hepatitis A virus infection. J Virol. 1988;62:3756–3763. Of interest. - PMC - PubMed

    2. HAV-infected fibroblasts and peripheral blood lymphocytes from HAV-infected patients showed the induction of virus-specific T cells, which secrete HAV-specific human IFNγ.

    1. Anderson K.P., Fennie E.H., Yilma T. Enhancement of a secondary antibody response to vesicular stomatitis virus “G” protein by IFN-γ treatment at primary immunization. J Immunol. 1988;140:3599–3604. Of interest. - PubMed

    2. Administration of IFNγ enhanced the production of virus-neutralizing antibodies after VSV infection.

    1. Chen X.-Z., Yun J.S., Wagner T.E. Enhanced viral resistence in transgenic mice expressing the human beta 1 interferon. J Virol. 1988;62:3883–3887. Of interest. - PMC - PubMed

    2. Transgenic mice expressing human IFNβ in their serum showed an enhanced resistance to pseudorabies virus infection.

    1. Kerry J.A., Tymms M.J., Linnane A.W. Conserved amino acid residues arginine 33 and tyrosine 123 are critical for the antiviral activity of murine interferon-α1. Biochem Biophys Res Commun. 1988;155:714–719. Of interest. - PubMed

    2. Using oligonucleotide-directed site-specific mutagenesis, 2 conserved amino-acid residues could be determined. An arginine at position 33 and a tyrosine at 123 were important in maintaining an antiviral activity of IFNα in 1292 cells infected with encephalomyocarditis virus.