Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 May 16;11(5):5317-32.
doi: 10.3390/ijerph110505317.

A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania

Randall A Kramer  1 , Leonard E G Mboera  2 , Kesheni Senkoro  3 , Adriane Lesser  4 , Elizabeth H Shayo  5 , Christopher J Paul  1 , Marie Lynn Miranda  6
Affiliations
Randomized Controlled Trial

A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania

Randall A Kramer et al. Int J Environ Res Public Health. .

Erratum in

  • Int J Environ Res Public Health. 2014 Sep;11(9):8622-3

Abstract

The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1) a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2) vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding). The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A map of (a) Tanzania and (b) Mvomero district.
Figure 2
Figure 2
Factorial study design.
Figure 3
Figure 3
Randomly-selected run from the village selection procedure.
Figure 4
Figure 4
Map of selected villages.
See this image and copyright information in PMC

References

    1. World Malaria Report 2013. World Health Organization; Geneva, Switzerland: 2013.
    1. MoHSW . In: Medium Term Malaria Strategic Plan, 2008–2013. Ministry of Health and Social Welfare, editor. Ministry of Health and Social Welfare; Dar es Salaam, Tanzania: 2008.
    1. Gallup J.L., Sachs J.D. The economic burden of malaria. Amer. J. Trop. Med. Hyg. 2001;64:85–96. - PubMed
    1. Coleman P.G., Morel C., Shillcutt S., Goodman C., Mills A.J. A threshold analysis of the cost-effectiveness of artemisinin-based combination therapies in sub-Saharan Africa. Amer. J. Trop. Med. Hyg. 2004;71:196–204. - PubMed
    1. Fowler V.G., Lemnge M., Irare S.G., Malecela E., Mhina J., Mtui S., Mashaka M., Mtoi R. Efficacy of chloroquine on plasmodium falciparum transmitted at Amani, eastern Usambara Mountains, north-east Tanzania: An area where malaria has recently become endemic. J. Trop. Med. Hyg. 1993;96:337–345. - PubMed

Publication types

MeSH terms

LinkOut - more resources