Toward a personalized medicine approach to the management of inflammatory bowel disease

Mahmoud H Mosli¹, William J Sandborn², Richard B Kim³, Reena Khanna⁴, Bandar Al-Judaibi⁵, Brian G Feagan⁴

Affiliations

¹ 1] Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada [2] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada [3] Department of Medicine, Division of Gastroenterology, King Abdulaziz University, Jeddah, Saudi Arabia.
² 1] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada [2] Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.
³ Department of Medicine, Division of Clinical Pharmacology, Western University, London, Ontario, Canada.
⁴ 1] Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada [2] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada.
⁵ 1] Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada [2] Department of Medicine, Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

PMID: 24842338
DOI: 10.1038/ajg.2014.110

Review

Toward a personalized medicine approach to the management of inflammatory bowel disease

Mahmoud H Mosli et al. Am J Gastroenterol. 2014 Jul.

. 2014 Jul;109(7):994-1004.

doi: 10.1038/ajg.2014.110. Epub 2014 May 20.

Authors

Mahmoud H Mosli¹, William J Sandborn², Richard B Kim³, Reena Khanna⁴, Bandar Al-Judaibi⁵, Brian G Feagan⁴

Affiliations

¹ 1] Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada [2] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada [3] Department of Medicine, Division of Gastroenterology, King Abdulaziz University, Jeddah, Saudi Arabia.
² 1] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada [2] Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.
³ Department of Medicine, Division of Clinical Pharmacology, Western University, London, Ontario, Canada.
⁴ 1] Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada [2] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada.
⁵ 1] Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada [2] Department of Medicine, Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

PMID: 24842338
DOI: 10.1038/ajg.2014.110

Abstract

The medical management of inflammatory bowel disease (IBD) is evolving toward a personalized medicine-based model. Modern therapeutic algorithms that feature use of tumor necrosis factor (TNF) antagonists in combination with immunosuppressive are highly effective when initiated in high-risk patients early in the course of disease. Defined targets that guide intensification of therapy are critical interventions. In this model, therapy is optimized through appropriate pretreatment testing, therapeutic drug monitoring, and patient-based monitoring strategies. This review discusses the current application of personalized medicine to the management of IBD.

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"Are you a gastroenterologist or a philosopher?".
Baty V. Baty V. Am J Gastroenterol. 2015 Jan;110(1):198. doi: 10.1038/ajg.2014.358. Am J Gastroenterol. 2015. PMID: 25567182 No abstract available.

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Toward a personalized medicine approach to the management of inflammatory bowel disease

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Toward a personalized medicine approach to the management of inflammatory bowel disease

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