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Review
. 2014 May 19:2014:bcr2013203318.
doi: 10.1136/bcr-2013-203318.

Acute promyelocytic leukaemia (APL) in a patient with Crohn's disease and exposure to infliximab: a rare clinical presentation and review of the literature

Farhan Mohammad  1 , Abhirami Vivekanandarajah  1 , Housam Haddad  1 , Christopher M Shutty  2 , Matthew T Hurford  2 , Qun Dai  1
Affiliations
Review

Acute promyelocytic leukaemia (APL) in a patient with Crohn's disease and exposure to infliximab: a rare clinical presentation and review of the literature

Farhan Mohammad et al. BMJ Case Rep. .

Abstract

With the introduction of potent immunosuppressive and chemotherapeutic medications for various diseases, there is an increased incidence of therapy-related myeloid neoplasms. They are the result of mutational rearrangement and historically, have a grave prognosis compared with de novo myeloid neoplasms. We did a short review on various types of myeloid leukaemias reported after therapy with antitumour necrosis factor and also report, to the best of our knowledge, one among the very few cases of therapy-related acute promyelocytic leukaemia in a patient on infliximab therapy for refractory Crohn's disease. The patient responded well to the traditional treatment and is in complete remission for more than 5 years.

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Figures

Figure 1
Figure 1
The bone marrow biopsy section showing moderate cellularity with aggregates of promyelocytes (×400).
Figure 2
Figure 2
High power image showing promyelocytes identified by their relative uniformity with abundant cytoplasm and oval-to-round nuclei that are often eccentrically located (×1000).
See this image and copyright information in PMC

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