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. 1989 Nov;22(2):179-88.
doi: 10.1007/BF02916648.

The effect of tetrathiomolybdate on the metabolism of copper by hepatocytes and fibroblasts

H J McArdle  1 , S M Gross, H M Vogel, M L Ackland, D M Danks
Affiliations

The effect of tetrathiomolybdate on the metabolism of copper by hepatocytes and fibroblasts

H J McArdle et al. Biol Trace Elem Res. 1989 Nov.

Abstract

Tetrathiomolybdate (TTM) has been examined for its effect on copper metabolism in mouse hepatocytes in primary culture and human fibroblasts. It decreased the amount of copper inside hepatocytes, decreased the rate of copper uptake by hepatocytes in a concentration dependent manner, and increased the copper efflux from the cells. TTM appeared to remove copper preferentially from the labile pool, but with a lower affinity than cage chelators. In fibroblasts, TTM only had a marginal effect on copper levels below a concentration of 100 microM and had no clear effect on the rate of copper uptake. TTM was not toxic to human fibroblasts, but in some preparations, a concentration of more than 50 microM was toxic to hepatocytes.

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