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Case Reports
. 2014 Jun:19 Suppl 3:49-51.
doi: 10.1111/nep.12251.

Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft

Kiyoshi Setoguchi  1 , Yoichiro Kawashima, Tadahiko Tokumoto, Hiroshi Toma, Shogo Mizoguchi, Shigeru Horita, Yutaka Yamaguchi, Kazunari Tanabe
Affiliations
Case Reports

Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft

Kiyoshi Setoguchi et al. Nephrology (Carlton). 2014 Jun.

Abstract

We herein describe the unique case of a 59-year-old man who underwent living kidney transplantation for IgA nephropathy (IgAN) and developed progressive kidney failure associated with the appearance of proliferative glomerulonephritis. An early protocol biopsy revealed recurrent IgAN with mesangial IgA2 deposits restricted to a single immunoglobulin λ light-chain isotype. Despite treatment with tonsillectomy and rituximab, the patient eventually lost his allograft 31 months after transplantation. Serum electrophoresis showed a monoclonal IgA pattern. This case might share common pathological characteristics with the newly described entity referred to as proliferative glomerulonephritis with monoclonal IgG deposits.

Keywords: glomerulonephritis; immunoglobulin A; kidney transplantation; membranoproliferative; rituximab.

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