Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug 20;3(4):352-3.
doi: 10.1111/j.2040-1124.2012.00227.x.

Role of sodium-glucose transporters in glucose uptake of the intestine and kidney

Affiliations

Role of sodium-glucose transporters in glucose uptake of the intestine and kidney

Norio Harada et al. J Diabetes Investig. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Glucose absorption through sodium‐dependent glucose transporter 1 (SGLT1) in (a) an enterocyte and (b) an enteroendocrine cell, and (c) glucose reabsorption through SGLT1 and sodium‐dependent glucose transporter 2 (SGLT2) in a proximal renal tubular cell. ADP, adenosine diphosphate; ATP, adenosine triphosphate; GIP, gastric inhibitory polypeptide; GLP‐1, glucagon‐like peptide‐1; GLUT, glucose transporter; SUR1, sulfonylurea receptor 1; VDCC, voltage‐dependent calcium channel.

References

    1. Gorboulev V, Schürmann A, Vallon V, et al Na(+)‐D‐glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose‐dependent incretin secretion. Diabetes 2012; 61: 187–196 - PMC - PubMed
    1. Reimann F, Habib AM, Tolhurst G, et al Glucose sensing in L cells: a primary cell study. Cell Metab 2008; 8: 532–539 - PMC - PubMed
    1. Gribble FM, Williams L, Simpson AK, et al A novel glucose‐sensing mechanism contributing to glucagon‐like peptide‐1 secretion from the GLUTag cell line. Diabetes 2003; 52: 1147–1154 - PubMed
    1. Yamane S, Harada N, Hamasaki A, et al Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance. J Diabetes Invest 2012; 3: 80–85 - PMC - PubMed
    1. Moriya R, Shirakura T, Ito J, et al Activation of sodium–glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. Am J Physiol Endocrinol Metab 2009; 297: E1358–E1365 - PubMed

LinkOut - more resources