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. 2014 Jun 23;53(26):6791-4.
doi: 10.1002/anie.201403823. Epub 2014 May 20.

Nickel-catalyzed α-arylation of ketones with phenol derivatives

Ryosuke Takise  1 , Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
Affiliations

Nickel-catalyzed α-arylation of ketones with phenol derivatives

Ryosuke Takise et al. Angew Chem Int Ed Engl. .

Abstract

The nickel-catalyzed α-arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α-arylketones. For this transformation, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt) was identified as a new, enabling, air-stable ligand for this transformation. The intermediate of an assumed C-O oxidative addition was isolated and characterized by X-ray crystal-structure analysis.

Keywords: CO activation; nickel; oxidative addition; synthetic methods; α-arylation.

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