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Editorial
. 2014 Aug;14(8):1049-53.
doi: 10.1517/14712598.2014.920814. Epub 2014 May 20.

Probody therapeutics for targeting antibodies to diseased tissue

Krishna R Polu  1 , Henry B Lowman
Affiliations
Editorial

Probody therapeutics for targeting antibodies to diseased tissue

Krishna R Polu et al. Expert Opin Biol Ther. 2014 Aug.

Abstract

Probodies are proteolytically activated antibodies engineered to remain inert until activated locally in diseased tissue. In principle, any therapeutic antibody can be converted into Probody™ form. In this perspective, we highlight the emerging therapeutic potential of the Probody approach in the form of conventional IgG-based Probodies as well as in the form of 'empowered Probody' formats such as Probody-drug conjugates.

Keywords: EGFR; Jagged; antibody; antibody–drug conjugate; bispecific antibody; chimeric antigen receptor – T cells; probody; protease.

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