PharmGKB summary: tramadol pathway

doi:10.1097/FPC.0000000000000057

. 2014 Jul;24(7):374-80.

doi: 10.1097/FPC.0000000000000057.

PharmGKB summary: tramadol pathway

Li Gong¹, Ulrike M Stamer, Mladen V Tzvetkov, Russ B Altman, Teri E Klein

Affiliations

Affiliation

¹ Departments of aGenetics bBioengineering, Stanford University, Stanford, California, USA cDepartment of Anaesthesiology and Pain Medicine, Inselspital dDepartment of Clinical Research, University of Bern, Bern, Switzerland eInstitute of Clinical Pharmacology, University Medical Center, Göttingen, Germany.

PMID: 24849324
PMCID: PMC4100774
DOI: 10.1097/FPC.0000000000000057

PharmGKB summary: tramadol pathway

Li Gong et al. Pharmacogenet Genomics. 2014 Jul.

. 2014 Jul;24(7):374-80.

doi: 10.1097/FPC.0000000000000057.

Authors

Li Gong¹, Ulrike M Stamer, Mladen V Tzvetkov, Russ B Altman, Teri E Klein

Affiliation

¹ Departments of aGenetics bBioengineering, Stanford University, Stanford, California, USA cDepartment of Anaesthesiology and Pain Medicine, Inselspital dDepartment of Clinical Research, University of Bern, Bern, Switzerland eInstitute of Clinical Pharmacology, University Medical Center, Göttingen, Germany.

PMID: 24849324
PMCID: PMC4100774
DOI: 10.1097/FPC.0000000000000057

No abstract available

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Figures

**Fig. 1**
Stylized liver cell showing candidate genes involved in the metabolism and transport of tramadol. A fully interactive version is available online at http://www.pharmgkb.org/pathway/PA165946349.

See this image and copyright information in PMC

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References

1. Reeves RR, Burke RS. Tramadol: basic pharmacology and emerging concepts. Drugs Today (Barc) 2008;44:827–836. - PubMed
1. Leppert W. Tramadol as an analgesic for mild to moderate cancer pain. Pharmacol Rep. 2009;61:978–992. - PubMed
1. Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs. 2000;60:139–176. - PubMed
1. Beaulieu AD, Peloso PM, Haraoui B, Bensen W, Thomson G, Wade J, et al. Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial. Pain Res Manag. 2008;13:103–110. - PMC - PubMed
1. Kanaan M, Daali Y, Dayer P, Desmeules J. Uptake/efflux transport of tramadol enantiomers and O-desmethyltramadol: focus on P-glycoprotein. Basic Clin Pharmacol Toxicol. 2009;105:199–206. - PMC - PubMed

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[1] Reeves RR, Burke RS. Tramadol: basic pharmacology and emerging concepts. Drugs Today (Barc) 2008;44:827–836. - PubMed

[2] Reeves RR, Burke RS. Tramadol: basic pharmacology and emerging concepts. Drugs Today (Barc) 2008;44:827–836. - PubMed

[3] Leppert W. Tramadol as an analgesic for mild to moderate cancer pain. Pharmacol Rep. 2009;61:978–992. - PubMed

[4] Leppert W. Tramadol as an analgesic for mild to moderate cancer pain. Pharmacol Rep. 2009;61:978–992. - PubMed

[5] Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs. 2000;60:139–176. - PubMed

[6] Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs. 2000;60:139–176. - PubMed

[7] Beaulieu AD, Peloso PM, Haraoui B, Bensen W, Thomson G, Wade J, et al. Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial. Pain Res Manag. 2008;13:103–110. - PMC - PubMed

[8] Beaulieu AD, Peloso PM, Haraoui B, Bensen W, Thomson G, Wade J, et al. Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial. Pain Res Manag. 2008;13:103–110. - PMC - PubMed

[9] Kanaan M, Daali Y, Dayer P, Desmeules J. Uptake/efflux transport of tramadol enantiomers and O-desmethyltramadol: focus on P-glycoprotein. Basic Clin Pharmacol Toxicol. 2009;105:199–206. - PMC - PubMed

[10] Kanaan M, Daali Y, Dayer P, Desmeules J. Uptake/efflux transport of tramadol enantiomers and O-desmethyltramadol: focus on P-glycoprotein. Basic Clin Pharmacol Toxicol. 2009;105:199–206. - PMC - PubMed

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PharmGKB summary: tramadol pathway

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