Comment

. 2014 Jun;14(6):449-50.

doi: 10.1016/S1473-3099(14)70777-7.

Artemisinin resistance in Plasmodium falciparum

Chanaki Amaratunga¹, Benoit Witkowski², Nimol Khim², Didier Menard², Rick M Fairhurst³

Affiliations

¹ Laboratory of Malaria and Vector Research, NIAID/National Institutes of Health, Rockville, MD 20852, USA.
² Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
³ Laboratory of Malaria and Vector Research, NIAID/National Institutes of Health, Rockville, MD 20852, USA. Electronic address: rfairhurst@niaid.nih.gov.

PMID: 24849722
PMCID: PMC4573664
DOI: 10.1016/S1473-3099(14)70777-7

Comment

Artemisinin resistance in Plasmodium falciparum

Chanaki Amaratunga et al. Lancet Infect Dis. 2014 Jun.

. 2014 Jun;14(6):449-50.

doi: 10.1016/S1473-3099(14)70777-7.

Authors

Chanaki Amaratunga¹, Benoit Witkowski², Nimol Khim², Didier Menard², Rick M Fairhurst³

Affiliations

¹ Laboratory of Malaria and Vector Research, NIAID/National Institutes of Health, Rockville, MD 20852, USA.
² Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
³ Laboratory of Malaria and Vector Research, NIAID/National Institutes of Health, Rockville, MD 20852, USA. Electronic address: rfairhurst@niaid.nih.gov.

PMID: 24849722
PMCID: PMC4573664
DOI: 10.1016/S1473-3099(14)70777-7

No abstract available

PubMed Disclaimer

Conflict of interest statement

We declare that we have no conflicts of interest.

Figures

**Figure 1**
Associations between parasite survival rates in the in-vitro RSA^0-3h, parasite clearance half-lives in patients treated with artemisinin-based combination therapy, and K13-propeller alleles: wild-type (clear), R539T (blue), C580Y (red), and Y493H (yellow).

See this image and copyright information in PMC

Comment on

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies.
Witkowski B, Amaratunga C, Khim N, Sreng S, Chim P, Kim S, Lim P, Mao S, Sopha C, Sam B, Anderson JM, Duong S, Chuor CM, Taylor WR, Suon S, Mercereau-Puijalon O, Fairhurst RM, Menard D. Witkowski B, et al. Lancet Infect Dis. 2013 Dec;13(12):1043-9. doi: 10.1016/S1473-3099(13)70252-4. Epub 2013 Sep 11. Lancet Infect Dis. 2013. PMID: 24035558 Free PMC article.

Cited by

Observing in real time the evolution of artemisinin resistance in Plasmodium falciparum.
Sibley CH. Sibley CH. BMC Med. 2015 Mar 31;13:67. doi: 10.1186/s12916-015-0316-5. BMC Med. 2015. PMID: 25889405 Free PMC article.
The endoplasmic reticulum chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites.
Kudyba HM, Cobb DW, Fierro MA, Florentin A, Ljolje D, Singh B, Lucchi NW, Muralidharan V. Kudyba HM, et al. Cell Microbiol. 2019 Sep;21(9):e13042. doi: 10.1111/cmi.13042. Epub 2019 Jun 6. Cell Microbiol. 2019. PMID: 31087747 Free PMC article.
Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012-2013.
Torrentino-Madamet M, Fall B, Benoit N, Camara C, Amalvict R, Fall M, Dionne P, Ba Fall K, Nakoulima A, Diatta B, Diemé Y, Ménard D, Wade B, Pradines B. Torrentino-Madamet M, et al. Malar J. 2014 Dec 4;13:472. doi: 10.1186/1475-2875-13-472. Malar J. 2014. PMID: 25471113 Free PMC article.
Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity.
Kite WA, Melendez-Muniz VA, Moraes Barros RR, Wellems TE, Sá JM. Kite WA, et al. Malar J. 2016 Feb 17;15:94. doi: 10.1186/s12936-016-1148-2. Malar J. 2016. PMID: 26888201 Free PMC article.
Molecular Epidemiology of Malaria in Cameroon and Côte d'Ivoire. XXXI. Kelch 13 Propeller Sequences in Plasmodium falciparum Isolates before and after Implementation of Artemisinin-Based Combination Therapy.
Djaman JA, Olefongo D, Ako AB, Roman J, Ngane VF, Basco LK, Tahar R. Djaman JA, et al. Am J Trop Med Hyg. 2017 Jul;97(1):222-224. doi: 10.4269/ajtmh.16-0889. Am J Trop Med Hyg. 2017. PMID: 28719312 Free PMC article.

See all "Cited by" articles

References

1. Witkowski B, Amaratunga C, Khim N, Sreng S, Chim P, Kim S, et al. Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. The Lancet infectious diseases. 2013;13(12):1043–9. - PMC - PubMed
1. Lopera-Mesa TM, Doumbia S, Chiang S, Zeituni AE, Konate DS, Doumbouya M, et al. Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity. J Infect Dis. 2013;207(11):1655–63. - PMC - PubMed
1. Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. 2014;505(7481):50–5. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

Z01 AI001000/ImNIH/Intramural NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Artemisinin resistance in Plasmodium falciparum

Affiliations

Artemisinin resistance in Plasmodium falciparum

Authors

Affiliations

Conflict of interest statement

Figures

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources