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Case Reports
. 2014 May 6:7:663-6.
doi: 10.2147/OTT.S60782. eCollection 2014.

Primary small-cell neuroendocrine carcinoma of the male breast: a rare case report with review of the literature

Jian Jiang  1 , Guixin Wang  1 , Li Lv  2 , Caigang Liu  1 , Xi Liang  1 , Haidong Zhao  1
Affiliations
Case Reports

Primary small-cell neuroendocrine carcinoma of the male breast: a rare case report with review of the literature

Jian Jiang et al. Onco Targets Ther. .

Abstract

In this case study and review, we present a case of a primary small-cell neuroendocrine carcinoma (SCNC) of the male breast. Primary SCNC of the breast is a rare tumor with less than 30 cases reported in the literature. Most cases are found in women. Another exceptional point is that human epidermal growth factor receptor-2 (Her-2) immunoreactivity was positive in our recent case, which differed to previous reports detailing SCNC in women. We have no evidence to demonstrate the differences between treatment and prognoses for males and females, because we do not have sufficient cases to undertake an evidence-based investigation. We provide this rare case history; review the literature on SCNC of the breast; and discuss detailed information regarding epidemiology, histogenesis, clinical and histologic diagnosis criteria, surgical and adjuvant treatment, and prognosis.

Keywords: SCNC neoplasm; SMCC; male breast cancer; neuroendocrine; small-cell carcinoma.

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Figures

Figure 1
Figure 1
Histology of the breast tumor tissue. Note: Tumor predominantly composed of small cells with hyperchromatic nuclei demonstrating chromatin diffusion and resembling “oat cell” carcinoma of the lung.
Figure 2
Figure 2
Tumor nucleolus showing cytokinesis. Notes: The tumor tissue nucleolus was inconspicuous and cytokinesis was general. Cancer cells were oval shaped and had finely granular nuclear chromatin with uniform and vesicular nuclei and relatively eosinophilic cytoplasm.
See this image and copyright information in PMC

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