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Review
. 2014 May;29(3):291-5.
doi: 10.3904/kjim.2014.29.3.291. Epub 2014 Apr 29.

The renin-angiotensin system and aging in the kidney

Hye Eun Yoon  1 , Bum Soon Choi  1
Affiliations
Review

The renin-angiotensin system and aging in the kidney

Hye Eun Yoon et al. Korean J Intern Med. 2014 May.

Abstract

Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose the elderly to various fluid and electrolyte imbalances as well as acute kidney injury and chronic kidney disease. Among the multiple pathways involved in renal aging, the RAS plays a central role. This review summarizes the association of the RAS with structural and functional changes in the aging kidney and age-related renal injury, and describes the underlying mechanisms of RAS-related renal aging. An improved understanding of the renal aging process may lead to better individualized care of the elderly and improved renal survival in age-related diseases.

Keywords: Aging; Kidney; Renin-angiotensin system.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

References

    1. Wetzels JF, Kiemeney LA, Swinkels DW, Willems HL, den Heijer M. Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study. Kidney Int. 2007;72:632–637. - PubMed
    1. Esposito C, Plati A, Mazzullo T, et al. Renal function and functional reserve in healthy elderly individuals. J Nephrol. 2007;20:617–625. - PubMed
    1. Davies DF, Shock NW. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest. 1950;29:496–507. - PMC - PubMed
    1. Hoang K, Tan JC, Derby G, et al. Determinants of glomerular hypofiltration in aging humans. Kidney Int. 2003;64:1417–1424. - PubMed
    1. Zhou XJ, Rakheja D, Yu X, Saxena R, Vaziri ND, Silva FG. The aging kidney. Kidney Int. 2008;74:710–720. - PubMed

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