Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Apr;12(1):19-30.
doi: 10.9758/cpn.2014.12.1.19. Epub 2014 Apr 24.

Advanced pharmacotherapy evidenced by pathogenesis of autism spectrum disorder

Yeon Jung Lee  1 , Soo Hyun Oh  2 , Chanmin Park  1 , Minha Hong  3 , Ah Rah Lee  4 , Hee Jeong Yoo  5 , Chan Young Shin  6 , Keun-Ah Cheon  7 , Geon Ho Bahn  1
Affiliations
Review

Advanced pharmacotherapy evidenced by pathogenesis of autism spectrum disorder

Yeon Jung Lee et al. Clin Psychopharmacol Neurosci. 2014 Apr.

Abstract

In clinical practice, pharmacological treatment is mostly focused on behavioral symptoms in everyday life. Nevertheless, persistent effort continues to develop medication for causal treatment. Recent changes in diagnostic criteria from Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR) to DSM-5 would affect not only diagnosing approaches, but also therapeutic approaches. Because previous pervasive developmental disorders have been integrated into a single entity, the autism spectrum disorder (ASD), we have to prepare for what medications are valuable for the ASD. In this article, we reviewed the following etiological treatment: acetylcholine and glutamate related medicine; amino acid medicine such as secretin, endogenous opioid, and oxytocin; complementary and alternative medicine such as chelating agents, vitamins, and omega-3; promising drugs related to the scope of pharmacogenetics currently under study.

Keywords: Child development disorders, pervasive; Drug therapy; Etiology.

PubMed Disclaimer

References

    1. Volkmar FR, Lord C, Bailey A, Schultz RT, Klin A. Autism and pervasive developmental disorders. J Child Psychol Psychiatry. 2004;45:135–170. - PubMed
    1. Leyfer OT, Folstein SE, Bacalman S, Davis NO, Dinh E, Morgan J, et al. Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. J Autism Dev Disord. 2006;36:849–861. - PubMed
    1. Baio J. Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ. 2012;61:1–19. - PubMed
    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association; 2013.
    1. Zuddas A. Autism assessment tools in the transition from DSM-IV to DSM-5. Eur Child Adolesc Psychiatry. 2013;22:325–327. - PubMed