Maintenance of morphology and tumour marker production in human epidermoid lung carcinoma xenografts
- PMID: 2485134
Maintenance of morphology and tumour marker production in human epidermoid lung carcinoma xenografts
Abstract
The histopathology and the expression of various marker substances including cytokeratin, epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA) of ten human epidermoid lung carcinoma xenograft lines were compared with the corresponding donor patient tumours. It was found that the histological structure and the tumour markers were maintained by the xenografts. Neoplastic cells were more effectively detected using anti-keratin antibodies as compared to antibodies against EMA. CEA immunoreactivity was more common in well differentiated tumours. With the aid of electron microscopy, the known cellular heterogeneity of epidermoid lung carcinomas in man was also confirmed in these xenografts.
Similar articles
-
[Morphologic and tumor-marker studies of human planocellular carcinoma of the bronchi in xenografts].Morphol Igazsagugyi Orv Sz. 1989 Apr;29(2):81-8. Morphol Igazsagugyi Orv Sz. 1989. PMID: 2747666 Hungarian.
-
Immunocytochemical evaluation of primary human esophageal carcinomas and their xenografts for keratin, beta-chorionic gonadotropin, placental lactogen, alpha-fetoprotein, carcinoembryonic antigen, and nonspecific cross-reacting antigen.Cancer Res. 1986 Nov;46(11):5730-7. Cancer Res. 1986. PMID: 2428482
-
Comparative histopathology of human epidermoid lung carcinoma xenografts.Strahlenther Onkol. 1989 Jul;165(7):485-6. Strahlenther Onkol. 1989. PMID: 2749470 No abstract available.
-
[Immunohistochemical markers in lung tumors--a status evaluation].Pneumologie. 1991 Apr;45(4):140-6. Pneumologie. 1991. PMID: 1876590 Review. German.
-
Biological studies of ten human squamous carcinoma cell lines: an overview.Eur J Cancer Clin Oncol. 1986 Jun;22(6):617-34. doi: 10.1016/0277-5379(86)90158-6. Eur J Cancer Clin Oncol. 1986. PMID: 2427339 Review.
Cited by
-
Development of drug resistance in a human epidermoid lung carcinoma xenograft line.Br J Cancer. 1988 Jul;58(1):30-3. doi: 10.1038/bjc.1988.155. Br J Cancer. 1988. PMID: 3166890 Free PMC article.
-
Induced multidrug resistance in murine leukemia L1210 and associated changes in a surface-membrane glycoprotein.J Cancer Res Clin Oncol. 1989;115(1):17-24. doi: 10.1007/BF00391594. J Cancer Res Clin Oncol. 1989. PMID: 2563999 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials